Acesulfame (potassium)

Acesulfame potassium is a synthetic sweetener. Long-term use of Acesulfame potassium can affect cognitive function, possibly by altering the neurometabolic functions in mice. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1 pathway, which may be related to immune evasion in cancer cells. Acesulfame potassium can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion^[1][2][3][4]. In Vitro:Acesulfame (1 mM, 24 hours) upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells^[2].
Acesulfame (1 mM, 24 hours) increases granzyme B production in RIL-175 and SK-Hep1 cells co-cultured with T cells^[2].
Acesulfame (1 mM, 24 hours) activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells^[2].
. Acesulfame (5-25 mM, 24 hours) inhibites mitochondrial metabolism in SH-SY5Y cells^[4].
Acesulfame (5-25 mM, 24 hours) inhibites ATP production in cells and reduced phosphorylation of neuroprotective proteins, impaires energy metabolism and neuroprotective functions in SH-SY5Y cells^[4]. In Vivo:Acesulfame (37.5 mg/kg, p.o., once daily for 4 weeks) potassium increases body weight in male CD-1 mice and altered their gut microbiome composition^[3].
Acesulfame (12.5 mM, administered via drinking water for 40 weeks) potassium affects the neurometabolic functions in C57BL/6J mice^[4].