Benzene-1,3,5-tricarboxylic acid

Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006)^[1][2]. In Vitro:Benzene-1,3,5-tricarboxylic acid forms hydrogen-bonding interactions with chitosan^[2].
Benzene-1,3,5-tricarboxylic acid (10-50 mM) can crosslink chitosan to form stable shear-thinning hydrogels^[2].
Chitosan hydrogels cross-linked with Benzene-1,3,5-tricarboxylic acid (10-50 mM) enable sustained release of 5-Fluorouracil (HY-90006), and their release profiles depend on the concentrations of trimesic acid and chitosan as well as pH value^[2].