Phytosphingosine

Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes^[1][2][3][4]. IC50 & Target:IC50: 33.4 μM (GPR120)^[4]. In Vitro: Phytosphingosine (200-400 μg/mL; 60-240 min) can inhibit the growth of Gram-positive and Gram-negative bacteria, yeast, and molds, and significantly inhibit the release of IL-1a, exhibiting anti-inflammatory activity^[1].
Phytosphingosine (1-5 μg/mL; 24-48 h) inhibits lung adenoma cell proliferation by inducing G2/M phase arrest, apoptosis and mitochondria-dependent pathway cell death in A549 and LLC cells, with IC₅₀ values of 4.3 μg/mL and 4.5μg/mL, respectively^[2].
Phytosphingosine (80 μM; 1-10 days) has antibacterial activity and can inhibit the growth ofS. sclerotiorum, S. indica and V. longisporum^[3].
In Vivo: Phytosphingosine (0.5-2 mg/kg; Intraperitoneal injection; once every other day for 10 times) has anti-tumor activity in C57BL/6 mice with lung cancer^[2].