3-Methoxytyramine

3-Methoxytyramine, a well known extracellular metabolite of 3-hydroxytyramine/dopamine, is a neuromodulator. IC50 & Target: The major extracellular metabolite of dopamine, 3-Methoxytyramine (3-MT), can induce behavioral effects in a dopamine-independent manner and these effects are partially mediated by the trace amine associated receptor 1 (TAAR1). 3-Methoxytyramine causes a significant increase in the level of phosphorylated Erk2, thus indicating that certain receptor-mediated processes in striatal cells are affected by this treatment. 3-Methoxytyramine activates TAAR1-mediated signaling in vitro. 3-Methoxytyramine induces activation of human TAAR1 in cAMP assay and causes CREB and Erk2 phosphorylation in HEK-293 cells^[1]. In Vivo: The extracellular dopamine (DA) metabolite 3-methoxytyramine (3-MT) induces significant behavioral activation in dopamine-deficient DAT-KO (DDD) mice. 3-Methoxytyramine induces behavioral activation and intracellular signaling in the striatum of DA deficient mice^[1].