Vidarabine
CAS No. : 5536-17-4
(Synonyms: Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine)
| Size | Price | Stock |
|---|---|---|
| 1g | $5 | In-stock |
| 5g | $12 | In-stock |
| 10g | $14 | In-stock |
| 25g | $19 | In-stock |
| 100g | $74 | In-stock |
| 500g | $363 | In-stock |
| 1000g | $670 | In-stock |
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| Cat. No. : | HY-B0277 |
| M.Wt: | 267.25 |
| Formula: | C10H13N5O4 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis[1][2][3].
IC50 & Target:DNA/RNA Synthesis[1]
In Vitro:Vidarabine (18-1200 μg/mL; 48 h) exhibits bactericidal activity against Candida albicans, with an MIC50 and MFC of 150 μg/mL and 300 μg/mL, respectively[3].
Vidarabine (150-300 μg/mL; 4-24 h) induces intracellular ROS accumulation, nuclear pyknosis, late-stage apoptosis and cell cycle arrest in Candida albicans cells, and reduces their ergosterol content[3].
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