Costunolide
CAS No. : 553-21-9
(Synonyms: (+)-Costunolide; Costus lactone)
| Size | Price | Stock |
|---|---|---|
| 5mg | $56 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $157 | In-stock |
| 50mg | $228 | In-stock |
| 100mg | $320 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-N0036 |
| M.Wt: | 232.32 |
| Formula: | C15H20O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 49 mg/mL;Ethanol : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].
IC50 & Target:Apoptosis[2][3]
In Vitro: Costunolide inhibits the colony formation, migrative and invasive abilities of the H1299 cells in a dose or time dependent manner[2].
Costunolide (6.7-215.2 μM; 24 hours) inhibits the viability of H1299 cells in a dose-dependent manner, with an IC50 of 23.93 μM[2].
Costunolide (12.0-48.0 μM; 48 hours) induces apoptosis in H1299 cells[2].
Costunolide (12-48.0 μM; 6-12 hours) regulates metastasis- and proliferation-associated mRNA expression[2].
Costunolide regulates epithelial-to-mesenchymal transition (EMT)-associated protein expression[2].
Costunolide regulates c-Myc mediated apoptosis signaling and 14-3-3-mediated signaling pathways in breast cancer cells[3].
In Vivo: Costunolide (20 mg/kg; i.p; daily; for 30 days) inhibits breast cancer through c-Myc/p53 and AKT/14-3-3 pathway[3].
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