Paeonol

Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC₅₀ of 54.6 μM and 42.5 μM, respectively. IC50 & Target:IC50: 42.5 μM (MAO-B), 54.6 μM (MAO-A)^[1] In Vitro:Paeonol is found to be inhibitory against MAO A in a dose-dependent manner with IC₅₀ value of 54.6 μM. Paeonol is shown to inhibit MAO-B in a dose-dependent manner with the IC₅₀ of 42.5 μM. For Paeonol, the K_i is estimated to be 51.1 μM. The inhibition of Paeonol on MAO B is of competitive type with K_i value of 38.2 μM^[1]. In Vivo:The 200 mg/kg Paeonol+I/R group [AN/V (%): 7.6±2.2, p<0.01] and 100 mg/kg Paeonol+I/R group [AN/V (%): 9.4±2.8, p<0.05] both show lesser extents of no-reflow area in the ventricles compared with the I/R group [AN/V (%): 18.2±2.9]. In particular, the 200 mg/kg Paeonol + I/R group experienced markedly alleviated no-reflow in the whole heart [AN/WH (%): 4.6±1, p<0.05] compared with the I/R group [AN/WH (%): 10.0±1.9]^[2].