| Size | Price | Stock |
|---|---|---|
| 1mg | $30 | In-stock |
| 5mg | $55 | In-stock |
| 10mg | $75 | In-stock |
| 25mg | $120 | In-stock |
| 50mg | $176 | In-stock |
| 100mg | $258 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-N0778 |
| M.Wt: | 624.54 |
| Formula: | C28H32O16 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Isorhamnetin-3-O-neohespeidoside is a flavonoid. Isorhamnetin-3-O-neohespeidoside can be isolated from Typha angustifolia. Isorhamnetin-3-O-neohespeidoside inhibits xanthine oxidase activity with an IC50 of 48.75 μg mL. Isorhamnetin-3-O-neohespeidoside has antioxidant and osteoclastogenic activities. Isorhamnetin-3-O-neohespeidoside can be used in research of bone[1][2][3].
IC50 & Target:xanthine oxidase: IC50 of 48.75 μg mL
In Vitro:Isorhamnetin-3-O-neohespeidoside (greater than 0.025 mg/mL) scavenges ABTS+• free radicals in a concentration-dependent manner with an IC50 of 0.06 mg/mL[2].
Isorhamnetin-3-O-neohespeidoside (19-150 μg/mL) inhibits xanthine oxidase activity with an IC50 of 48.75 μg mL and scavenges superoxide anions with an IC50 of 30 μg mL[2].
Isorhamnetin-3-O-neohespeidoside (1-50 μM; 4 days) promotes RANKL-induced osteoclastogenesis in BMMs in a dose-dependent manner, increasing the number and area of TRAP-positive osteoclasts[3].
In Vivo:Isorhamnetin-3-O-neohespeidoside (18.75 mg/kg; gingival injection; 4 days) promotes resorption of crown-covered bone, increases the number of TRAP-positive osteoclasts, and upregulates RANKL protein expression in the crown coverage of dental follicle in C57BL/6 mice[3].
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