Isorhamnetin-3-O-neohespeidoside


CAS No. : 55033-90-4

55033-90-4
Price and Availability of CAS No. : 55033-90-4
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Cat. No. : HY-N0778
M.Wt: 624.54
Formula: C28H32O16
Purity: >98 %
Solubility: DMSO : 250 mg/mL (ultrasonic)
Introduction of 55033-90-4 :

Isorhamnetin-3-O-neohespeidoside is a flavonoid. Isorhamnetin-3-O-neohespeidoside can be isolated from Typha angustifolia. Isorhamnetin-3-O-neohespeidoside inhibits xanthine oxidase activity with an IC50 of 48.75 μg mL. Isorhamnetin-3-O-neohespeidoside has antioxidant and osteoclastogenic activities. Isorhamnetin-3-O-neohespeidoside can be used in research of bone[1][2][3]. IC50 & Target:xanthine oxidase: IC50 of 48.75 μg mL In Vitro:Isorhamnetin-3-O-neohespeidoside (greater than 0.025 mg/mL) scavenges ABTS+• free radicals in a concentration-dependent manner with an IC50 of 0.06 mg/mL[2].
Isorhamnetin-3-O-neohespeidoside (19-150 μg/mL) inhibits xanthine oxidase activity with an IC50 of 48.75 μg mL and scavenges superoxide anions with an IC50 of 30 μg mL[2].
Isorhamnetin-3-O-neohespeidoside (1-50 μM; 4 days) promotes RANKL-induced osteoclastogenesis in BMMs in a dose-dependent manner, increasing the number and area of TRAP-positive osteoclasts[3].
In Vivo:Isorhamnetin-3-O-neohespeidoside (18.75 mg/kg; gingival injection; 4 days) promotes resorption of crown-covered bone, increases the number of TRAP-positive osteoclasts, and upregulates RANKL protein expression in the crown coverage of dental follicle in C57BL/6 mice[3].

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