Naphazoline (hydrochloride)
CAS No. : 550-99-2
(Synonyms: Naphthazoline (hydrochloride))
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| Cat. No. : | HY-B0446 |
| M.Wt: | 246.74 |
| Formula: | C14H15ClN2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 25 mg/mL;H2O : 50 mg/mL (ultrasonic) |
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research[1][2]. In Vivo: Naphazoline hydrochloride (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].
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