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Busulfan


CAS No. : 55-98-1

55-98-1
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Cat. No. : HY-B0245
M.Wt: 246.30
Formula: C6H14O6S2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic);Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL
Introduction of 55-98-1 :

Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent[1][2][3]. In Vitro:Busulfan (120 μM; 24 h) incited a moderate p53 activation, but strong Erk, p38, and JNK phosphorylation, in a time-dependent manner[1].
Busulfan (120 μM; 24 h) results in premature senescence in WI38 cells via the Erk and p38 MAPK pathway, reduces GSH and increases ROS production, but the production can be suppressed by NADPH oxidase[1].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Busulfan can be used to induce aplastic anemia models. In mice, after injections of Busulfan at doses of 16.5 mg/kg and 33 mg/kg, the measured areas under the curve are 220±34 h·nmol·mL-1 and 604±87 h·nmol·mL-1, respectively[7].

Induction of Aplastic Anemia Model[6]
Background
Busulfan causes DNA damage by cross-linking DNA as well as DNA and proteins.
Specific Modeling Methods
Mice : ICR • male • 18-22 g, 6-8 weeks
Administration: 20 mg/kg busulfan+40 mg/kg cyclophosphamide• i.p. • one time per day for 12 days.
Note
(1) Twenty-four hours after the last intraperitoneal injection, tail vein blood was collected from eight mice randomly selected from each group for blood test.
(2) the mice are sacrificed by cervical dislocation and one femur was surgically dissected. After removing epiphysis from the femur, bone marrow cells are washed off using 1 ml PBS to prepare bone marrow cell suspension.
Modeling Indicators
The peripheral blood cells, hemoglobin, and bone marrow nucleated cells decreased significantly.
Histopathological: the proliferation of bone marrow hematopoietic tissues and cells was inhibited, and non-hematopoietic cells (fat cells) were significantly increased.
Correlated Product(s): Cyclophosphamide (HY-17420)

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