Busulfan
CAS No. : 55-98-1
| Size | Price | Stock |
|---|---|---|
| 500mg | $55 | In-stock |
| 1g | $79 | In-stock |
| 5g | $118 | In-stock |
| 10g | $155 | In-stock |
| 25g | $230 | In-stock |
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| Cat. No. : | HY-B0245 |
| M.Wt: | 246.30 |
| Formula: | C6H14O6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL |
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic drug[1][2][3].
In Vitro:Busulfan (120 μM; 24 h) incited a moderate p53 activation, but strong Erk, p38, and JNK phosphorylation, in a time-dependent manner[1].
Busulfan (120 μM; 24 h) results in premature senescence in WI38 cells via the Erk and p38 MAPK pathway, reduces GSH and increases ROS production, but the production can be suppressed by NADPH oxidase[1].
In Vivo:Busulfan (40 mg/kg; i.p; single dose) increases apoptosis and decreases the testis weight in mice[4].
Busulfan (2.5, 5.0 mg/kg, i.p.) causes earlier occurrence of persistent esturs in a dose dependent manner in rats. Busulfan (5.0 mg/kg) also increases the incidence of uterine adenocarcinomas and multiplicity of uterine neoplastic lesions[5]
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