Guanethidine
CAS No. : 55-65-2
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| Cat. No. : | HY-B1251 |
| M.Wt: | 198.31 |
| Formula: | C10H22N4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres. In Vitro:Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro[1].. In Vivo:Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1(-/-) mice as a sympathetic blocker[2]..
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