McN-A-343
CAS No. : 55-45-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $160 | In-stock |
| 100mg | $250 | In-stock |
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| Cat. No. : | HY-107648 |
| M.Wt: | 317.21 |
| Formula: | C14H18Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine (HY-121404)-evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319)-induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis[1][2][3].
In Vitro:McN-A-343 (30 μM) produces a significant inhibitory effect on muscarine-evoked catecholamine secretion from the isolated perfused rat adrenal gland[2].
In Vivo:McN-A-343 (0.5-1.5 mg/kg, i.p., single dose) reduces colonic macroscopic lesion scores in Acetic acid (HY-Y0319)-induced ulcerative colitis mice[1].
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