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Scopolamine (hydrochloride)


CAS No. : 55-16-3

(Synonyms: (-)-Scopolamine (hydrochloride); Hyoscine (hydrochloride))

55-16-3
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Cat. No. : HY-B2065
M.Wt: 339.81
Formula: C17H22ClNO4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 55-16-3 :

Scopolamine (Hyoscine) hydrochloride is a high-affinity muscarinic antagonist that can cross the blood-brain barrier. Scopolamine hydrochloride competitively antagonizes 5-HT3 receptors with an IC50 of 2.09 μM. Scopolamine hydrochloride can induce cognitive and memory deficits in animals. Scopolamine hydrochloride can be used in the research of preventing postoperative nausea and vomiting, motion sickness, nervous system diseases, etc[1][2][3][4][5]. In Vitro:Scopolamine hydrochloride blocks nicotinic acetylcholine receptors (IC50 = 928 μM) and increases the expression of α7 nACh receptors. Scopolamine hydrochloride displays concentration-dependent competition with 0.6 nM [3H]Granisetron, yielding an average pKi of 5.17 (Ki = 6.76 μM). Concentration-dependent competition of fluorescently labeled form of Granisetron (HY-B0071) with Scopolamine hydrochloride gives an average pKi of 5.31 (Ki = 4.90 μM).Scopolamine hydrochloride blocks muscarinic receptors and induces a cognitive deficit[1].
Scopolamine (0.1-3 mM; for 24 hours) hydrochloride induces cytotoxicity, ROS generation and apoptosis of SH-SY5Y cells[6].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Scopolamine (1 mg/kg; i.p.; once) induces memory impairment associated with attenuation of cholinergic neurotransmission, as well as an increases of processes connected with oxidative stress in the brain in mice[7].
Scopolamine can be used to induce memory impairment models[4].

Induction of Memory Impairment
Background
Scopolamine is a selective acetylcholine receptor antagonist, which reduces the effectiveness of acetylcholin at the synapse through ocupation of the receptor sites on the post-synaptic membrane.
Specific Modeling Methods
Mice: Mus musculus Swiss • 2 months old • 25-30 g
Administration: 1 mg/kg/day for 7 days
Note
Modeling Indicators
Behavior-T-maze test: Increased latency time to enter the preferred arm. Reduced number of entries and time staying in the preferred arm, while increased number of entries and time staying in the discrminated arm.
Behavior-Locomotion activity in open field: Decreased time spent in the centre of the open field. Decreased number of crossing and rearing.
Behavior-Object recognition: Increased time to discover and stay with the familiar object. Decreased number of exploration of the novel object.
Molecular changes: Decreased level of glutathione. Increased activity of acetylcholinesterase in brain.
Correlated Product(s): Streptozotocin (HY-13753); Lipopolysaccharide (HY-D1056)
Opposite Product(s): Tacrine (HY-111338); Rivastigmine (HY-17368); Donepezil (HY-14566)

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