Norswertianolin
CAS No. : 54954-12-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $460 | In-stock |
| 10mg | $740 | In-stock |
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| Cat. No. : | HY-N6617 |
| M.Wt: | 422.34 |
| Formula: | C19H18O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Norswertianolin acts as a CSE activator and is isolated from G. acuta. Norswertianolin may be a potential agent for cardiovascular diseases[1][2].
IC50 & Target:CSE[2]
In Vitro: Norswertianolin (3.125~50 μM; H9c2 cells) has the protective effects on H2O2-induced H9c2 cells. Norswertianolin significantly increases the transcription levels of HO-1 and GCLC in H9c2 cells[1]. Norswertianolin (0~150 μM; HepG2 cells) high concentration increases the CSE protein level[2].
In Vivo: Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H2S production[2].
Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2].
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