Meglitinide
CAS No. : 54870-28-9
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| Cat. No. : | HY-15210 |
| M.Wt: | 333.77 |
| Formula: | C17H16ClNO4 |
| Purity: | >98 % |
| Solubility: |
Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 μM, 0.53 μM and 1.6 μM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 μM for both SUR1 and SUR2A, and a Kd value of 8 μM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes[1]. In Vitro:Meglitinide blocks recombinant Kir6.2/SUR1, Kir6.2/SUR2A, and Kir6.2/SUR2B KATP channels with similar affinities, with IC50 values ranging from 0.26 to 1.6 μmol/l across the channel subtypes[1].
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