Dapansutrile


CAS No. : 54863-37-5

54863-37-5
Price and Availability of CAS No. : 54863-37-5
Size Price Stock
50mg $122 In-stock
100mg $178 In-stock
250mg $257 In-stock
1g $644 In-stock
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Cat. No. : HY-17629
M.Wt: 133.17
Formula: C4H7NO2S
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL;H2O : 36.67 mg/mL (ultrasonic)
Introduction of 54863-37-5 :

Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases[1][2]. In Vivo: Dapansutrile (3.75 g/kg; p.o.; daily, for 22 d) ameliorates neurological decline and nervous tissue damage in experimental autoimmune encephalomyelitis (EAE) mice[1].
Dapansutrile (3.75 g/kg; p.o.; daily, for 22 d) attenuates the protein levels of pro-inflammatory cytokines in the spinal cord of experimental autoimmune encephalomyelitis (EAE) mice[1].
Dapansutrile (6-600 mg/kg; i.p.; once; male ICR (CD1) mice) reduces infarct size and reduces caspase-1 activity in the heart[2].
Dapansutrile (6-600 mg/kg; i.p.; once, for 24 hours and 7 days; mice subjected to acute myocardial infarction) preserves cardiac function following myocardial ischemia-reperfusion injury[2].

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