Quercetagitrin
CAS No. : 548-75-4
(Synonyms: Quercetagetin-7-O-glucoside)
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $195 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $850 | In-stock |
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| Cat. No. : | HY-N4150 |
| M.Wt: | 480.38 |
| Formula: | C21H20O13 |
| Purity: | >98 % |
| Solubility: |
Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimer’s disease and type 2 diabetes[1][2][3][4].
In Vitro:Quercetagitrin (3.12-100 μM, 0-48 h) decreases the peak flurorescence and inhibits tau-K18 aggregation in a dose-dependent manner[3].
Quercetagitrin (10-40 μM, 24 h) decreases tau phosphorylation levels and total tau levels concentration-dependently in HEK293 cells transfected with human 1N4R P301S-tau plasmids sup>[3].
Quercetagitrin (10-20 μM, 24 h) decreases tau phosphorylation levels and total tau levels concentration-dependently in N2a cells transfected with human 1N4R P301S-tau plasmids sup>[3].
Quercetagitrin (Compound QG) inhibits PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM)[4].
Quercetagitrin (2.5-5 μM, 6 h) increases glucose absorption in the prescence of insulin in differentiated C2C12 myoblasts[4].
Quercetagitrin (5-10 μM, 6 h) increases AMPK phosphorylation in C2C12 myoblasts[4].
Quercetagitrin (40 μM, 6 h) mitigates palmitic acid-induced insulin resistance in C2C12 myoblast through the insulin-dependent Akt pathway[4].
In Vivo:Quercetagitrin (10 μg/mL, through water feeding, 3 consecutive months) attenuates synaptic impairments and cognitive deficits in the P301S-Tau transgenic mice[3].
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