Isoginkgetin
CAS No. : 548-19-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $271 | In-stock |
| 100mg | $435 | In-stock |
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| Cat. No. : | HY-N2117 |
| M.Wt: | 566.51 |
| Formula: | C32H22O10 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2].
In Vitro:Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner[1].
Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification[2].
Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates[2].
Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling[2].
Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines[2].
In Vivo:Isoginkgetin (4 mg/kg; i.p.; daily for 14 days) shows anti-inflammatory effects[3].
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