Roemerine

Roemerine is an alkaloid that has been identified from the leaves of Fibraurea recisa Pierre. Roemerine exhibits antibacterial, anticancer, and antidepressant activities, can reverse the multidrug resistance phenotype in cultured cells, and exerts antibacterial effects by regulating the cAMP signaling pathway. Additionally, Roemerine influences neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems. Roemerine holds promise for research in the fields of cancer, infections, and neurological diseases^{[1][2][3][4][5]}. In Vitro:Roemerine (0-1 mM, 48 h) significantly reduces cell viability in RM-1 cells, with IC₅₀ of 1177.4 µM ^[2].
Roemerine (8 µg/mL, 8 h) can influence biofilm formation in Candida albicans SC5314 through the regulation of the cAMP signaling pathway^[3].
Roemerine (10 μM， 48 h) affects neuronal activity by increasing BDNF protein expression and modulating the serotonergic and glutamatergic systems in SH-SY5Y cells, exhibiting antidepressant-like effects^[4].
In Vivo:Roemerine (30 mg/kg, i.p., once every three days for 30 days) significantly inhibited tumor growth in the prostate cancer BALB/C nude mouse model (established by subcutaneous implantation of RM-1 cells)^[2].
Roemerine (20 mg/kg, i.p., once daily for 2 days) increases survival and reduced bacterial loads in multiple organs in the MRSA XJ75302-induced sepsis BALB/C mouse model^[5].