Inosine-5'-diphosphate (disodium)

Inosine-5'-diphosphate disodium (IDP disodium) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate disodium has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate disodium abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research^[1][2][3]. In Vitro:Inosine-5'-diphosphate disodium disrupts the interactions between NM23-H2 and c-MYC G-Quadruplex (Pu27-GQ). Inosine-5'-diphosphate disodium binds to the Guanosine diphosphate-binding pocket of NM23-H2 (K_d = 5.0 μM). Inosine-5'-diphosphate disodium synergizes c-MYC transcription-silencing effects of Pu27-GQ-binding ligands. Inosine-5'-diphosphate disodium has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate disodium can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research^[1][2][3].