Hyocholic acid
CAS No. : 547-75-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $820 | In-stock |
| 100mg | $1300 | In-stock |
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| Cat. No. : | HY-121238 |
| M.Wt: | 408.57 |
| Formula: | C24H40O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C) |
Hyocholic Acid is a bile acid found in pig. Hyocholic Acid can also be found in urine samples from patients with cholestasis. Hyocholic Acid promotes GLP-1 secretion via activating TGR5 and inhibiting FXR in enteroendocrine cells. Hyocholic Acid is known for its exceptional resistance to type 2 diabetes [1][2][3].
In Vitro: HCA (25 and 50 μM, 24 h) upregulates GLP-1 protein secretion in STC-1 and NCI-H716 cells[3].
HCA (25 and 50 μM, 24 h) upregulates proglucagon gene transcription in STC-1 and NCI-H716 cells[3].
In Vivo: Hyocholic Acid (20 mg/kg, p.o.) suppresses BA depletion-induced blood glucose increase in pigs[3].
Hyocholic Acid (100 mg/kg/day, p.o.) improves serum fasting GLP-1 secretion and glucose homeostasis in diabetic mouse models[3].
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