Sulfadiazine (sodium)
CAS No. : 547-32-0
| Size | Price | Stock |
|---|---|---|
| 100g | $50 | In-stock |
| 500g | $175 | In-stock |
| 1000g | $298 | In-stock |
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| Cat. No. : | HY-B0273A |
| M.Wt: | 272.26 |
| Formula: | C10H9N4NaO2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Sulfadiazine sodium is an orally active sulfonamide antibiotic. Sulfadiazine sodium competitively inhibits p-aminobenzoic acid in the folic-acid-metabolism cycle, inhibiting multiplication of most Gram-positive and many Gram-negative bacteria. Sulfadiazine sodium persists in soil long-term, and exerts selective pressure for sulfonamide-resistant microbial populations. Sulfadiazine sodium targets Toxoplasma gondii DHPS enzyme. Sulfadiazine sodium can be used for the research of congenital toxoplasmosis and bacterial infection[1][2][3][4]. In Vitro:Sulfadiazine sodium is associated with low sensitivity linked to the novel R265H and I347M mutations in the dhps gene of Toxoplasma gondii strains TgCTBr4 and TgCTBr17[3]. In Vivo:Sulfadiazine (10-640 mg/kg/d; p.o.; daily for 10 days) sodium reduced the number of brain cysts in mice infected with T. gondii (TgCTBr) except for TgCTBr4[3].
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