α-Thujone
CAS No. : 546-80-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $192 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $545 | In-stock |
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| Cat. No. : | HY-121618 |
| M.Wt: | 152.24 |
| Formula: | C10H16O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and can cross the blood-brain barrier[1][2][3].
In Vitro:α-Thujone (66 μM-3.2 mM, 24-96 h) inhibits the proliferation of glioblastoma multiforme (GBM) cells T98G and U87, inhibits the migration and invasion of GBM cell by affecting cytoskeletal proteins[2].
α-Thujone (66 μM-3.2 mM, 24-96 h) induces the formation of autophagosomes (GFP) and autophagolysosomes (RFP), induces autophagy in T98G cells[2].
In Vivo:α-Thujone (30-60 mg/kg, ip, single dose) induces epileptic seizures and death in mice[3].
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