Conessine
CAS No. : 546-06-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $425 | In-stock |
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| Cat. No. : | HY-107566 |
| M.Wt: | 356.59 |
| Formula: | C24H40N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C);Ethanol : 25 mg/mL (ultrasonic) |
Conessine is an orally active and BBB-penetrable selective histamine H3 receptor antagonist. The pKi values of Conessine for rat and human H3 receptors are 7.61 and 8.27, respectively. Conessine is an inhibitor of the multidrug efflux pump system in Pseudomonas aeruginosa and can enhance the activity of antibiotics. Conessine has antimalarial activity. Conessine can also be used in the research of muscle atrophy[1][2][3][4][5].
In Vitro:Conessine (2.5-20 μM; 24 h) inhibits p53-, NF-κB-, and FoxO3a-dependent transcription in HEK293 cells[1].
Conessine (10 μM) reduces the levels of MuRF1 and atrogin-1 in Dexamethasone (HY-14648)-treated C2C12 myotube cells[1].
Conessine (72 h) has antimalarial activity, with IC50 values of 1.9 and 1.3 μg/mL in the schizont maturation method and pLDH assay, respectively[2].
Conessine (74 h) is cytotoxic to L-6 cells, with an IC50 of 14 μg/mL[2].
In Vivo:Conessine (10-50 mg/kg; oral administration; 4 days) significantly reduces parasitaemia in mice infected with P. berghei[2].
Conessine (0.1-10 mg/kg; subcutaneously; single dose) can exacerbate ethanol-induced psychostimulant effects in mice[3].
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