Nizofenone
CAS No. : 54533-85-6
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| Cat. No. : | HY-119513 |
| M.Wt: | 412.87 |
| Formula: | C21H21ClN4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke[1][2][3].
In Vitro: Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3].
Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3].
Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3].
Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4].
In Vivo: Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments[1].
Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats[2].
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