Methyl protodioscin
CAS No. : 54522-52-0
(Synonyms: NSC-698790; Smilax saponin B)
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $175 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $450 | In-stock |
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| Cat. No. : | HY-N0863 |
| M.Wt: | 1063.23 |
| Formula: | C52H86O22 |
| Purity: | >98 % |
| Solubility: | H2O : 25 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest. IC50 value: Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2].
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