Uvaol

Uvaol, a triterpene present in olives and virgin olive oil, possesses anti-inflammatory properties and antioxidant effects. Uvaol is an orally active inducer of apoptosis in astroglioma cells. Uvaol also has anti-cancer activities. Uvaol attenuates pleuritis and eosinophilic inflammation in ovalbumin-induced allergy in mice^[1][2]. In Vitro:Uvaol (25-50 μM; for 6-18 h) induces morphological changes in 1321N1 astrocytoma cells in the cell morphology experiment, causing cells to contract, round up and detach from the culture support, and also alters the expression levels of cell-surface proteins ICAM-1, VCAM-1 and CD44^[2].
Uvaol (1-50 μM; for 18 h) inhibits DNA synthesis in 1321N1 astrocytoma cells in the cell proliferation experiment, showing a dose-dependent growth-inhibitory effect^[2].
Uvaol (25-100 μM; for 18 h) induces apoptosis in 1321N1 astrocytoma cells in the apoptosis experiment, resulting in a sub-diploid peak in the cell cycle, increasing the outer leaflet of phosphatidylserine on the cell surface, and the apoptotic rate increases in a dose-dependent manner^[2].
Uvaol (25-100 μM; 0.25-6 h) activates JNK in 1321N1 astrocytoma cells in the JNK activation experiment, and the activation is the strongest at 50 μM^[2].
Uvaol (5-50 μM; 6-18 h) promotes the accumulation of intracellular reactive oxygen species (ROS) and reduces the mitochondrial membrane potential in 1321N1 astrocytoma cells in the ROS production experiment^[2].
In Vivo:Uvaol (100-500 μmol/kg; orally administered; 60 min before antigen challenge) can reduce pleural eosinophilic inflammation and IL-5 concentration in a murine pleurisy model induced by ovalbumin^[1].