JNJ-10181457
CAS No. : 544707-19-9
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| Cat. No. : | HY-107562A |
| M.Wt: | 312.45 |
| Formula: | C20H28N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
JNJ-10181457 is a selective non-imidazole histamine H3 receptor antagonist that normalizes acetylcholine neurotransmission[1]. JNJ-10181457 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vivo:JNJ 10181457 (1 mg/kg, i.v.) can completely block the inhibition of the vagally induced bradycardic responses produced by histamine (50 μg/kg) or methimepip (50 μg/kg) compared with saline control in male Wistar rats[1].
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