Surfen (dihydrochloride)
CAS No. : 5424-37-3
(Synonyms: Aminoquinuride (dihydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $105 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-122704A |
| M.Wt: | 445.34 |
| Formula: | C21H22Cl2N6O |
| Purity: | >98 % |
| Solubility: | H2O : 8 mg/mL (ultrasonic;warming) |
Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen dihydrochloride inhibits HSV-1 viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE[1][2][3][4][5][6].
IC50 & Target:IC50 of approximately 2 μM (uronyl 2-O-sulfotransferase)
In Vitro:Surfen (3 μM) dihydrochloride binds to glycosaminoglycans (GAGs)[1].
Surfen (1 mg) dihydrochloride neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins[1].
Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase, with an IC50 of ~2 μM[1].
Surfen (1-≥5 μM) dihydrochloride inhibits cell attachment in a dose-dependent manner, and completely inhibits HSV-1 infection in CHO cells[1].
Surfen (5 μM) dihydrochloride effectively inhibits neural differentiation and promotes the maintenance of pluripotency in mouse embryonic stem cells (mESCs)[2].
Surfen (2.5-20 μM) dihydrochloride reduces the proliferation of murine T cells activated with anti-CD3/CD28 antibody-coated T cell expander beads[6].
In Vivo:Surfen (3 μM; 2 days) dihydrochloride significantly reduces tau hyperphosphorylation, rescues spinal motoneuron axon-branching defects and behavioral deficits in Tg[HuC::hTauP301L; DsRed] embryos of zebrafish tauopathy model[4].
Surfen (5 mg/kg; i.p.; every other day) dihydrochloride alleviates clinical symptoms and reduces the infiltration of CD4 positive T cells and macrophages into the central nervous system in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis in mice[5].
Surfen (100 μM; injection into the right burr hole) dihydrochloride delays remyelination of the lesions in the Lysolecithin (LPC)-induced demyelination mouse model[5].
Surfen (20 mg/kg; i.p.; daily; 3 consecutive days) dihydrochloride inhibits the proliferation of T cells activated by anti-CD3 antibody in mice[6].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Surfen (dihydrochloride)
- Cat. No.:
- HY-122704A
- Quantity:
Your information is safe with us.