Aminoadipic acid
CAS No. : 542-32-5
| Size | Price | Stock |
|---|---|---|
| 1g | $19 | In-stock |
| 5g | $51 | In-stock |
| 10g | $92 | In-stock |
| 25g | $209 | In-stock |
| 100g | $769 | In-stock |
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| Cat. No. : | HY-113328 |
| M.Wt: | 161.16 |
| Formula: | C6H11NO4 |
| Purity: | >98 % |
| Solubility: | H2O : 2.86 mg/mL (ultrasonic);DMSO : 2 mg/mL (ultrasonic) |
Aminoadipic acid is an orally active lysine oxide derivative. Aminoadipic acid induces ROS generation, increases free Ca2+, decreases SOD, and activates TXNIP/NLRP3 pathway. Aminoadipic acid has pro-inflammatory effects. Aminoadipic acid can be used in atherosclerosis research[1][2][3][4].
In Vitro: Aminoadipic acid (1 μM-1 mM; 1 h) induces ROS generation and increases free Ca2+ and protein carbonyl levels in mouse pancreatic acinar cells[3].
Aminoadipic acid (419 ng/mL) induces inflammation by activating ROS/TXNIP/NLRP3 pathway in HUVEC cells[4].
In Vivo: Aminoadipic acid (1%-2%; p.o., added to drinking water; ad libitum; 13 weeks) aggravates atherosclerotic vascular inflammation in atherosclerotic ApoE-/- mice fed a high-fat diet[4].
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