Doxorubicinol
CAS No. : 54193-28-1
(Synonyms: Adriamycinol; DXR-OL)
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| Cat. No. : | HY-121259 |
| M.Wt: | 545.54 |
| Formula: | C27H31NO11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.
In Vitro: Doxorubicinol inhibits diastolic function (i.e., increased resting pressure) of isolated papillary muscles[1].
Doxorubicinol almost completely abrogates calcium pump activity at concentrations that significantly reduce diastolic function[1].
Doxorubicinol inhibits Ca2+-stimulated ATPase activity of the sarcoplasmic reticulum of skeletal muscle and abolishes Na+/K+-ATPase activity of the sarcolemma in canine and rabbit heart preparations[1].
Doxorubicinol inhibits the proliferation of PANC-1 cells with IC50 value of 35.4 μM, PD PaCa cells with IC50 value of 44.5 μM, WD PaCa cells with IC50 value of 49.5[1].
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