Rilmenidine
CAS No. : 54187-04-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $110 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-100490 |
| M.Wt: | 180.25 |
| Formula: | C10H16N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].
In Vitro: Rilmenidine provides antihypertensive efficacy comparable with that of diuretics, beta-blockers, calcium channel blockers, and angiotensin-converting enzyme (ACE) inhibitors[1].
Rilmenidine (25-100 μM; 24 hours) inhibits K562 cell proliferation[2].
In Vivo: Rilmenidine-treated N171-82Q mice (i.p.; 4-times a week) displays significant improved forelimb grip strength and all limbs grip strength from 12 to 22 weeks of age[3].
Rilmenidine decreases levels of mutant huntingtin[3].
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