Maleimide


CAS No. : 541-59-3

541-59-3
Price and Availability of CAS No. : 541-59-3
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Cat. No. : HY-W007324
M.Wt: 97.07
Formula: C4H3NO2
Purity: >98 %
Solubility: H2O : 50 mg/mL (ultrasonic);DMSO : ≥ 100 mg/mL
Introduction of 541-59-3 :

Maleimide can be used for production of antibody-drug conjugate (ADC) which is used in cancer research. Maleimide also be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes[1][2]. In Vitro:Maleimide binds rapidly and covalently to the sulfhydryl (-SH) group of cysteine residues, that can be used in the drug delivery system for improved cell uptake efficiency[3]. In Vivo:Maleimide modified liposome (M-GGLG-liposomes, 2 mg/kg, sc, twice in an interval of 2 weeks) exhibits antitumor in mouse models with a better and long-term efficacy[3].

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