Isovaleramide
CAS No. : 541-46-8
(Synonyms: 3-Methylbutanamide)
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| Cat. No. : | HY-B1229 |
| M.Wt: | 101.15 |
| Formula: | C5H11NO |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1][2][3][4].
In Vivo:Isovaleramide (100 mg/kg, p.o., a single dose at 4-hour following fasting) evidences a 90% index protection against the maximal electroshock seizure in mice[1].
Isovaleramide (10 and 20 mg/kg, i.v.,every 12 h for 48 h) reduces the mortality rate, attenuates the pathological damage of kidney tissues in EG-poisoned rats and down-regulates the expression of serum biomarkers of AKI[2].
Isovaleramide (100 mg/kg; p.o.) shows a 90% index protection against the maximal electroshock (MES)-induced seizure in mice, comparable to Sodium phenytoin (HY-B0448A)[4].
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