Zorubicin
CAS No. : 54083-22-6
(Synonyms: Rubidazon; Rubidazone)
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| Cat. No. : | HY-106556 |
| M.Wt: | 645.66 |
| Formula: | C34H35N3O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Zorubicin (Rubidazon) is a derivative of Daunorubicin (HY-13062A). Zorubicin interacts with topoisomerase II and inhibits DNA polymerases. Zorubicin can be used for the research of acute leukemias and sarcomas[1][2][3][4][5]. In Vitro: Zorubicin (0.1-1 μg/mL; 0-24 h) affects cell cycle[2]. Zorubicin (0-128 nM/mL; 20 min) dose-dependently inhibits DNA polymerases α and β, and shows preferential inhibition of polymerase α[3]. In Vivo: Zorubicin (12-18 mg/kg; i.p. 48 h after tumour cells injection) affects leukaemic colony forming units[1]. Zorubicin (0.75-6.0 mg/kg; i.v.) increases plasma histamine concentrations and produces immediate hypotension in anesthetized beagle dogs[3].
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