Iproniazid


CAS No. : 54-92-2

54-92-2
Price and Availability of CAS No. : 54-92-2
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Cat. No. : HY-B0886A
M.Wt: 179.22
Formula: C9H13N3O
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL
Introduction of 54-92-2 :

Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756)-induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity[1][2][3][4][5][6][7]. In Vitro:Iproniazid (10 mM; 24 h) increases intracellular dopamine content and accelerates DNA fragmentation induced by 0.1 μM Rotenone (HY-B1756) in SH-SY5Y cells[2].
Iproniazid (100 μM; 10 min) inhibits serotonin metabolism by monoamine oxidase in cultured guinea pig tracheal smooth muscle cells[3].
In Vivo:Iproniazid (100 mg/kg; i.p.; 150 min before Lidocaine administration) lowers the median convulsant dose of Lidocaine in mice, reducing the seizure threshold [4].
Iproniazid (i.p.) causes hepatic necrosis in Sprague-Dawley and Fischer rats[5].
Iproniazid dihydrochloride (53-224 mg/kg; p.o.; daily) retards sexual maturation, lengthens the estrous cycle, and inhibits corpus luteum formation in female rats[6].

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