Isoniazid
CAS No. : 54-85-3
(Synonyms: INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide)
| Size | Price | Stock |
|---|---|---|
| 100g | $18 | In-stock |
| 500g | $60 | In-stock |
| 1000g | $72 | In-stock |
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| Cat. No. : | HY-B0329 |
| M.Wt: | 137.14 |
| Formula: | C6H7N3O |
| Purity: | >98 % |
| Solubility: | H2O : 33.33 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Isoniazid (INH) is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme KatG. Isoniazid is bactericidal to rapidly dividing mycobacteria and has anti-tuberculostatic activity[1][2][3][4].
In Vitro: Isoniazid (INH) is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG[1].
KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824[2][3].
Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing[4].
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