WF-536
CAS No. : 539857-64-2
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| Cat. No. : | HY-118837 |
| M.Wt: | 277.75 |
| Formula: | C14H16ClN3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer[1]. In Vitro: WF-536 (1, 3, 10, 30, 100 μM) inhibits both invasion and migration by LLC cells and invasion, migration, and formation of capillarylike tubes on Matrigel by endothelial cells, without cytotoxicity or anti-proliferative action in either cell type[1]. In Vivo: WF-536 (oral; 0.3-3 mg/kg/day; for 28 days) inhibits Lewis lung carcinoma (LLC) metastasis and LLC-induced angiogenesis in mice[1].
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