3-Chloro-5-hydroxybenzoic acid
CAS No. : 53984-36-4
| Size | Price | Stock |
|---|---|---|
| 250mg | $12 | In-stock |
| 1g | $19 | In-stock |
| 5g | $59 | In-stock |
| 10g | $117 | In-stock |
| 25g | $270 | In-stock |
| 100g | $980 | In-stock |
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| Cat. No. : | HY-W016868 |
| M.Wt: | 172.57 |
| Formula: | C7H5ClO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].
In Vitro: 3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1].
In Vivo: 3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1].
Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1].
| dose (mg/kg) | tmax (h) | AUCinf (h ng/mL) | Cmax (ng/mL) | Cmax (μM) | t1/2 (h) |
| 30 | 0.5 | 9356 | 11689.50 | 67.2 | 1.47 |
| 100 | 0.5 | 51312 | 55252.80 | 341.9 | 1.10 |
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