Pentostatin
CAS No. : 53910-25-1
(Synonyms: CI-825; Deoxycoformycin)
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $285 | In-stock |
| 50mg | $542 | In-stock |
| 100mg | $870 | In-stock |
| 500mg | $2610 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-A0006 |
| M.Wt: | 268.27 |
| Formula: | C11H16N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;H2O : 100 mg/mL (ultrasonic) |
Pentostatin (CI-825; Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase with Ki of 2.5 pM. IC50 & Target:Ki: 2.5 pM (adenosine deaminase) In Vivo:In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL[1]. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups[2].
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