L-NIL
CAS No. : 53774-63-3
| Size | Price | Stock |
|---|---|---|
| 50mg | $90 | In-stock |
| 100mg | $140 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12116 |
| M.Wt: | 187.24 |
| Formula: | C8H17N3O2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : < 1 mg/mL |
L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3]. IC50 & Target:IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[1] In Vitro: L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[3]. In Vivo: L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1].
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