Mexiletine (hydrochloride)
CAS No. : 5370-01-4
(Synonyms: KOE-1173 (hydrochloride))
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| 500mg | $84 | In-stock |
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| Cat. No. : | HY-A0093 |
| M.Wt: | 215.72 |
| Formula: | C11H18ClNO |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 41 mg/mL;H2O : 100 mg/mL (ultrasonic) |
Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].
IC50 & Target:IC50: 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block (sodium channel of HEK293 transfected with hNav1.5 plasmid)[2]
In Vitro:Mexiletine (10µM, 48 h) increases peak INa and late INa in HEK293A cells transfected with SCN5A-WT or SCN5A-1795insD while Mexiletine (10µM, 5 min) blocks the late INa[3].
In Vivo:Mexiletine (30, 100 mg/kg, p.o., acute administration) reverses both mechanical allodynia and cold hyperalgesia in Oxaliplatin (HY-17371) induced rats[4].
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