QX-314 (chloride)
CAS No. : 5369-03-9
| Size | Price | Stock |
|---|---|---|
| 25mg | $60 | In-stock |
| 50mg | $100 | In-stock |
| 100mg | $160 | In-stock |
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| Cat. No. : | HY-108505 |
| M.Wt: | 298.85 |
| Formula: | C16H27ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 50 mg/mL (ultrasonic) |
QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].
IC50 & Target:sodium channel[1]
In Vitro:QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro[2].
QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner[2].
QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average < 45% of control amplitude[2].
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