QX-222 (chloride)
CAS No. : 5369-00-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-101362 |
| M.Wt: | 256.77 |
| Formula: | C13H21ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (486.82 mM; ultrasonic and warming and heat to 60°C) |
QX-222 chloride, a trimethyl analogue of Lignocaine (HY-B0185), is a potent Na+ channel blocker[1][2][3]. In Vitro: Twelve minutes after external application of 500 μM QX222 chloride, μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001)[1]. In Vivo: QX-222 (10 mg/kg; intravenous infusion 7 days) chloride reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats[2].
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