Dyclonine (hydrochloride)
CAS No. : 536-43-6
(Synonyms: Dyclocaine hydrochloride)
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| 5g | $66 | In-stock |
| 10g | $92 | In-stock |
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| Cat. No. : | HY-B0364A |
| M.Wt: | 325.87 |
| Formula: | C18H28ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 25 mg/mL;H2O : 50 mg/mL (ultrasonic) |
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain[1][2][3].
In Vitro: Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH[1].
Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity[2].
In Vivo: Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo[1].
Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine[1].
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