Ethionamide
CAS No. : 536-33-4
(Synonyms: 2-Ethylthioisonicotinamide)
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| Cat. No. : | HY-B0276 |
| M.Wt: | 166.25 |
| Formula: | C8H10N2S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity[1][2][3][4].
In Vitro:Ethionamide strongly inhibits mycolic acid synthesis in BCG strain Mycobacterium bovis cells. For M. tuberculosis Canetti, Mycobacterium sp. strain CR21, and ATCC 23366, the MIC values are 0.5, 3, and 60 μg/ml, respectively[2].
Ethionamide (60 μg/ml, 0-120 min) concurrently increases unsaturated mycolic acids and decreases oxygenated mycolic acids in M. aurum ATCC 23366[2].
Ethionamide's S-oxidation is primarily catalyzed by FMOs, particularly in the liver and lung[3].
In Vivo:
Pharmacokinetic parameters of ethionamide in mice[4]
| Sex | Tmax (h) | Cmax (μg/mL) |
| Male | 1 | 15.1±34.4 |
| Femal | 1±0.5 | 15.1±14.8 |