BPH-1358
CAS No. : 5352-53-4
(Synonyms: NSC50460)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $660 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-118946 |
| M.Wt: | 601.53 |
| Formula: | C32H30Cl2N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 4.04 mg/mL (ultrasonic;warming;heat to 60°C) |
BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. IC50 & Target: IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (undecaprenyl diphosphate synthase)[2] In Vitro: BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. In Vivo: BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1].
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