N,N'-Dimethylthiourea
CAS No. : 534-13-4
(Synonyms: DMTU)
| Size | Price | Stock |
|---|---|---|
| 5g | $10 | In-stock |
| 25g | $24 | In-stock |
| 100g | $90 | In-stock |
| 500g | $378 | In-stock |
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| Cat. No. : | HY-W027951 |
| M.Wt: | 104.17 |
| Formula: | C3H8N2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
N,N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2]. In Vivo: N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1].
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