NSC 1008
CAS No. : 5335-95-5
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| Cat. No. : | HY-124126 |
| M.Wt: | 326.40 |
| Formula: | C22H18N2O |
| Purity: | >98 % |
| Solubility: |
NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 μM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer[1].
In Vitro:NSC 1008 (compound 2) inhibits human Rce1 activity (IC50 = 8.9 μM)[1].
NSC 1008 (25 µM; 20 hours) exhibits low toxicity in HCT-116 cells[1].
NSC 1008 (25 µM; 20 hours) induces mislocalization of EGFP-H-Ras, EGFP-N-Ras, and EGFP-K-Ras4b in HCT-116 cells[1].
NSC 1008 (10-50 µM) demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase[1].
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