Aleuritic acid


CAS No. : 533-87-9

(Synonyms: (±)-erythro-Aleuritic acid; α-Aleuritic acid)

533-87-9
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Cat. No. : HY-N7076
M.Wt: 304.42
Formula: C16H32O5
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 533-87-9 :

Aleuritic acid ((±)-erythro-Aleuritic acid; α-Aleuritic acid) is a polyhydroxy fatty acid found in plant cutin and shellac. Aleuritic acid disrupts the Mycobacterium tuberculosis Nei2-β-clamp (DnaN) interaction and binds to the Mycobacterium tuberculosis β-clamp without affecting the intrinsic DNA glycosylase activity of Nei2. Aleuritic acid self-assembles with pectin to form cutin body nanoparticles. Aleuritic acid is the major component of Croton crassifolius. Aleuritic acid is used in mycobacterial and fragrance-related research[1][2][3]. In Vitro:Aleuritic acid (50-800 µM; 30 min) inhibits the interaction between Mycobacterium tuberculosis Nei2 and the β clamp with an IC50 of 71.49 µM, without affecting the intrinsic glycosylase activity of MtbNei2[2].
Aleuritic acid binds to the Mycobacterium tuberculosis β-clamp with a KD of 27 nM[2].

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